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1

Oxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor/sterol regulatory element binding protein–1c signaling pathway and reduces serum and hepatic lipids in mouse models of nonalcoholic fatty liver disease

Qianming Bai, Xin Zhang, Leyuan Xu, Genta Kakiyama, Douglas Heuman, Arun Sanyal, William M. Pandak, Lianhua Yin, Wen Xie, Shunlin Ren

Journal:

Year:

2012

Language:

english

File:

PDF, 1.33 MB

english, 2012

2

StarD5: an ER stress protein regulates plasma membrane and intracellular cholesterol homeostasis

Rodriguez-Agudo, Daniel, Malacrida, Leonel, Kakiyama, Genta, Sparrer, Tavis, Fortes, Carolina, Maceyka, Michael, Subler, Mark A., Windle, Jolene J., Gratton, Enrico, Pandak, William M., Gil, Gregorio

Journal:

The Journal of Lipid Research

Year:

2019

Language:

english

File:

PDF, 9.31 MB

english, 2019

3

Synthesis of 3α,7α,14α-Trihydroxy-5β-cholan-24-oic Acid: A Potential Primary Bile Acid in Vertebrates.

Genta Kakiyama, Takashi Iida, Takaaki Goto, Nariyasu Mano, Junichi Goto, Toshio Nambara

Journal:

Year:

2004

File:

PDF, 134 KB

2004

4

1H and 13C NMR signal assignments of carboxyl-linked glucosides of bile acids

Takashi Iida, Genta Kakiyama, Akari Shimada, Kumiko Mushiake, Nariyasu Mano, Junichi Goto, Toshio Nambara

Journal:

Magnetic Resonance in Chemistry

Year:

2003

Language:

english

File:

PDF, 140 KB

english, 2003

5

A direct method for the separation and quantification of bile acid acyl glycosides by high-performance liquid chromatography with an evaporative light scattering detector

Genta Kakiyama, Atsuko Hosoda, Takashi Iida, Yasuo Fujimoto, Takaaki Goto, Nariyasu Mano, Junichi Goto, Toshio Nambara

Journal:

Journal of Chromatography A

Year:

2006

Language:

english

File:

PDF, 196 KB

english, 2006

6

Chemical synthesis of 24-β-d-galactopyranosides of bile acids: a new type of bile acid conjugates in human urine

Genta Kakiyama, Shinji Sadakiyo, Takashi Iida, Kumiko Mushiake, Takaaki Goto, Nariyasu Mano, Junichi Goto, Toshio Nambara

Journal:

Chemistry and Physics of Lipids

Year:

2005

Language:

english

File:

PDF, 190 KB

english, 2005

7

Capillary gas chromatographic separation of bile acid acyl glycosides without thermal decomposition and isomerization

Takashi Iida, Shoujiro Ogawa, Genta Kakiyama, Takaaki Goto, Nariyasu Mano, Junichi Goto, Toshio Nambara

Journal:

Journal of Chromatography A

Year:

2004

Language:

english

File:

PDF, 141 KB

english, 2004

8

LC/ESI-tandem mass spectrometric determination of bile acid 3-sulfates in human urine: 3β-Sulfooxy-12α-hydroxy-5β-cholanoic acid is an abundant nonamidated sulfate

Takaaki Goto, Khin Than Myint, Koichi Sato, Osamu Wada, Genta Kakiyama, Takashi Iida, Takanori Hishinuma, Nariyasu Mano, Junichi Goto

Journal:

Journal of Chromatography B

Year:

2007

Language:

english

File:

PDF, 262 KB

english, 2007

9

Nuclear magnetic resonance spectroscopy of 3β,7β-dihydroxy-5-cholen-24-oic acid multi-conjugates: unusual bile acid metabolites in human urine

Genta Kakiyama, Shoujiro Ogawa, Takashi Iida, Yasuo Fujimoto, Kumiko Mushiake, Takaaki Goto, Nariyasu Mano, Junichi Goto, Toshio Nambara

Journal:

Chemistry and Physics of Lipids

Year:

2006

Language:

english

File:

PDF, 329 KB

english, 2006

10

Identification of a novel conjugate in human urine: bile acid acyl galactosides

Takaaki Goto, Akihiro Shibata, Daisuke Sasaki, Naoto Suzuki, Takanori Hishinuma, Genta Kakiyama, Takashi Iida, Nariyasu Mano, Junichi Goto

Journal:

Year:

2005

Language:

english

File:

PDF, 211 KB

english, 2005

11

Chemical synthesis of the 3-sulfooxy-7-N-acetylglucosaminyl-24-amidated conjugates of 3β,7β-dihydroxy-5-cholen-24-oic acid, and related compounds: Unusual, major metabolites of bile acid in a patient with Niemann-Pick disease type C1

Takashi Iida, Genta Kakiyama, Yohei Hibiya, Shohei Miyata, Takehiko Inoue, Kohsaku Ohno, Takaaki Goto, Nariyasu Mano, Junichi Goto, Toshio Nambara, Alan F. Hofmann

Journal:

Year:

2006

Language:

english

File:

PDF, 503 KB

english, 2006

12

A facile synthesis of C-24 and C-25 oxysterols by in situ generated ethyl(trifluoromethyl)dioxirane

Shoujiro Ogawa, Genta Kakiyama, Akina Muto, Atsuko Hosoda, Kuniko Mitamura, Shigeo Ikegawa, Alan F. Hofmann, Takashi Iida

Journal:

Year:

2009

Language:

english

File:

PDF, 322 KB

english, 2009

13

Chemical synthesis of 3β-sulfooxy-7β-hydroxy-24-nor-5-cholenoic acid: An internal standard for mass spectrometric analysis of the abnormal Δ5-bile acids occurring in Niemann-Pick disease

Genta Kakiyama, Akina Muto, Miki Shimada, Nariyasu Mano, Junichi Goto, Alan F. Hofmann, Takashi Iida

Journal:

Year:

2009

Language:

english

File:

PDF, 853 KB

english, 2009

14

Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells

Qianming Bai, Leyuan Xu, Genta Kakiyama, Melissa Ann Runge-Morris, Phillip B. Hylemon, Lianhua Yin, William M. Pandak, Shunlin Ren

Journal:

Atherosclerosis

Year:

2011

Language:

english

File:

PDF, 1.12 MB

english, 2011

15

Cholesterol metabolite, 5-cholesten-3β-25-diol-3-sulfate, promotes hepatic proliferation in mice

Xin Zhang, Qianming Bai, Genta Kakiyama, Leyuan Xu, Jin Kyung Kim, William M. Pandak Jr., Shunlin Ren

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2012

Language:

english

File:

PDF, 796 KB

english, 2012

16

Modulation of the fecal bile acid profile by gut microbiota in cirrhosis

Kakiyama, Genta, Pandak, William M., Gillevet, Patrick M., Hylemon, Phillip B., Heuman, Douglas M., Daita, Kalyani, Takei, Hajime, Muto, Akina, Nittono, Hiroshi, Ridlon, Jason M., White, Melanie B., N

Journal:

Journal of Hepatology

Year:

2013

Language:

english

File:

PDF, 655 KB

english, 2013

17

Su1682 A Simple and Accurate Method in the Analysis of Fecal Bile Acids by Conventional HPLC-UV Is Demonstrated in Cirrhotic Patients

Kakiyama, Genta, Muto, Akina, Takei, Hajime, Nittono, Hiroshi, Ikegawa, Shigeo, Ren, Shunlin, Pandak, William M., Bajaj, Jasmohan

Journal:

Gastroenterology

Year:

2013

Language:

english

File:

PDF, 173 KB

english, 2013

18

LC/ESI-MS/MS analysis of urinary 3β-sulfooxy-7β-N-acetylglucosaminyl-5-cholen-24-oic acid and its amides: New biomarkers for the detection of Niemann–Pick type C disease

Maekawa, Masamitsu, Misawa, Yasushi, Sotoura, Ayako, Yamaguchi, Hiroaki, Togawa, Masami, Ohno, Kousaku, Nittono, Hiroshi, Kakiyama, Genta, Iida, Takashi, Hofmann, Alan F., Goto, Junichi, Shimada, Miki

Journal:

Year:

2013

Language:

english

File:

PDF, 1.02 MB

english, 2013

19

281 Humanization of Germ-Free Mice With Alcoholic Cirrhotic Microbiota, but Not Healthy Microbiota, Induces Bacterial Translocation and a Pro-Inflammatory Milieu, Which Is Ameliorated With Lactobacillus GG

Kang, Daejoong, Hylemon, Phillip, Sartor, R. Balfour, Kakiyama, Genta, Gillevet, Patrick M., Heuman, Douglas M., Pandak, William M., Ridlon, Jason M., Grapov, Dmitry, Fiehn, Oliver, Bajaj, Jasmohan S.

Journal:

Gastroenterology

Year:

2015

Language:

english

File:

PDF, 354 KB

english, 2015

20

280 The Beneficial Impact of Rifaximin on Systemic and Intestinal Inflammation and Ammonia Occurs Even Without Microbiota: More Than an Antibiotic

Kang, Daejoong, Sartor, R. Balfour, Kakiyama, Genta, Betrapally, Naga, Herzog, Jeremy, Nittono, Hiroshi, Hylemon, Phillip, Zhou, Huiping, Carroll, Ian, Yang, Jin, Gillevet, Patrick M., Jiao, Chunhua,

Journal:

Gastroenterology

Year:

2016

Language:

english

File:

PDF, 870 KB

english, 2016

21

Rifaximin Exerts Beneficial Effects Independent of its Ability to Alter Microbiota Composition

Kang, Dae J, Kakiyama, Genta, Betrapally, Naga S, Herzog, Jeremy, Nittono, Hiroshi, Hylemon, Phillip B, Zhou, Huiping, Carroll, Ian, Yang, Jing, Gillevet, Patrick M, Jiao, Chunhua, Takei, Hajime, Pand

Journal:

Clinical and Translational Gastroenterology

Year:

2016

Language:

english

File:

PDF, 391 KB

english, 2016

22

Potential Corticoid Metabolites: Chemical Synthesis of 3- and 21-Monosulfates and Their Double-Conjugates of Tetrahydrocorticosteroids in the 5α- and 5β-Series

Okihara, Rika, Mitamura, Kuniko, Hasegawa, Maki, Mori, Megumi, Muto, Akina, Kakiyama, Genta, Ogawa, Shoujiro, Iida, Takashi, Shimada, Miki, Mano, Nariyasu, Ikegawa, Shigeo

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2010

Language:

english

File:

PDF, 894 KB

english, 2010

23

Synthesis of 3α,7α,14α-Trihydroxy-5β-cholan-24-oic Acid: A Potential Primary Bile Acid in Vertebrates

Kakiyama, Genta, Iida, Takashi, Goto, Takaaki, Mano, Nariyasu, Goto, Junichi, Nambara, Toshio

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2004

Language:

english

File:

PDF, 85 KB

english, 2004

24

Potential Bile Acid Metabolites. 25. Synthesis and Chemical Properties of Stereoisomeric 3α,7α,16- and 3α,7α,15-Trihydroxy-5β-cholan-24-oic Acids

Iida, Takashi, Hikosaka, Masahiro, Kakiyama, Genta, Shiraishi, Keisuke, Schteingart, Claudio D., Hagey, Lee R., Ton-Nu, Huong-Thu, Hofmann, Alan F., Mano, Nariyasu, Goto, Junichi, Nambara, Toshio

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2002

Language:

english

File:

PDF, 135 KB

english, 2002

25

Chemical Synthesis of (22E)-3α,6α,7α,12α-Tetrahydroxy-5β-chol-22-en-24-oic Acid and Its N-Acylamidated Conjugates with Glycine or Taurine: Precursors of the [22,23-3H] Labelled Tracers

Ogawa, Shoujiro, Adachi, Yuuki, Kakiyama, Genta, Shimada, Miki, Mano, Nariyasu, Goto, Junichi, Iida, Takashi

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2010

Language:

english

File:

PDF, 205 KB

english, 2010

26

Gut microbial composition can differentially regulate bile acid synthesis in humanized mice

Kang, Dae Joong, Hylemon, Phillip B, Gillevet, Patrick M, Sartor, R. Balfour, Betrapally, Naga S., Kakiyama, Genta, Sikaroodi, Masoumeh, Takei, Hajime, Nittono, Hiroshi, Zhou, Huiping, Pandak, William

Journal:

Hepatology Communications

Year:

2017

Language:

english

File:

PDF, 712 KB

english, 2017

27

Inflammasome Activation by Chronic Down Regulation of CYP7B1 and its Causative Increased Oxysterol Accumulation, Represents the Key Initial Step in Fatty Liver's Progression Toward Inflammation

Kakiyama, Genta, Marques, Dalila, Takei, Hajime, Nittono, Hiroshi, Liu, Xiaoying, Green, Richard M., Erickson, Sandra, Rodriguez-Agudo, Daniel, Gil, Gregorio, Bajaj, Jasmohan S., Hylemon, Phillip, Zho

Journal:

Gastroenterology

Year:

2017

Language:

english

File:

PDF, 881 KB

english, 2017

28

Continued Alcohol Misuse in Human Cirrhosis is Associated with An Impaired Gut-Liver Axis

Bajaj, Jasmohan S, Kakiyama, Genta, Zhao, Derrick, Takei, Hajime, Fagan, Andrew, Hylemon, Phillip, Zhou, Huiping, Pandak, William M, Nittono, Hiroshi, Fiehn, Oliver, Salzman, Nita, Holtz, Mary, Simpso

Journal:

Alcoholism: Clinical and Experimental Research

Year:

2017

Language:

english

File:

PDF, 551 KB

english, 2017

29

Alterations in Gut Microbial Function Following Liver Transplant

Bajaj, Jasmohan S., Kakiyama, Genta, Cox, I. Jane, Nittono, Hiroshi, Takei, Hajime, White, Melanie, Fagan, Andrew, Gavis, Edith A., Heuman, Douglas M., Gilles, Ho Chong, Hylemon, Phillip, Taylor-Robin

Journal:

Liver Transplantation

Year:

2018

Language:

english

File:

PDF, 963 KB

english, 2018

30

Antibiotic-Associated Disruption of Microbiota Composition and Function in Cirrhosis is Restored by Fecal Transplant

Bajaj, Jasmohan S, Kakiyama, Genta, Savidge, Tor, Takei, Hajime, Kassam, Zain A, Fagan, Andrew, Gavis, Edith A, Pandak, William M, Nittono, Hiroshi, Hylemon, Phillip B, Boonma, Prapaporn, Haag, Anthon

Journal:

Year:

2018

Language:

english

File:

PDF, 1.51 MB

english, 2018

31

Sterol carrier protein-2 deficiency attenuates diet-induced dyslipidemia and atherosclerosis in mice

He, Honglaing, Wang, Jing, Yannie, Paul J., Kakiyama, Genta, Korzun, William J., Ghosh, Shobha

Journal:

Journal of Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 3.06 MB

english, 2018

32

Su1491 - Western Diet Mediated Chronic Suppression of CYP7B1 Leads to Dysregulation of Intercellular Oxysterol Metabolism and Drives NAFLD to NASH

Kakiyama, Genta, Zhao, Derrick, Martin, Rebecca, Rodriguez-Agudo, Daniel, Marques, Dalila, Liu, Xiaoying, Green, Richard M., Erickson, Sandra, Conrad, Daniel H., Zhou, Huiping, Fuchs, Michael, Bajaj,

Journal:

Gastroenterology

Year:

2018

Language:

english

File:

PDF, 664 KB

english, 2018

33

Identification of Novel Regulatory Cholesterol Metabolite, 5-Cholesten, 3β,25-Diol, Disulfate

Ren, Shunlin, Kim, Jin Koung, Kakiyama, Genta, Rodriguez-Agudo, Daniel, Pandak, William M., Min, Hae-Ki, Ning, Yanxia, Zang, Mengwei

Journal:

Year:

2014

Language:

english

File:

PDF, 1.32 MB

english, 2014

34

Su1939 - Bile Acid 7α-Dehydroxylating Gut Clostridia: From Comparative Genomics to In Vivo Metatranscriptomics and Metabolomics to Gene Discovery

Ridlon, Jason M., Doden, Heidi, Ly, Lindsey, Volland, Alyssa, Mythen, Sean, Devendran, Saravanan, Sallam, Lina, Pereira, Gabriel, Cann, Isaac, Daniel, Steven, Kakiyama, Genta, Nittono, Hiroshi, Kashya

Journal:

Gastroenterology

Year:

2018

Language:

english

File:

PDF, 1.26 MB

english, 2018

35

803 - Antibiotic-Associated Disruption of Microbial Composition and Functionality is Restored after Fecal Microbial Transplant in Cirrhosis

Bajaj, Jasmohan S., Kakiyama, Genta, Savidge, Tor C., Fagan, Andrew, Gavis, Edith, Nittono, Hiroshi, Hylemon, Phillip, Boonma, Prapoporn, Haag, Anthony, Heuman, Douglas, Kassam, Zain, Sikaroodi, Masou

Journal:

Gastroenterology

Year:

2018

Language:

english

File:

PDF, 472 KB

english, 2018

36

Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids

Kang, Jason D., Myers, Christopher J., Harris, Spencer C., Kakiyama, Genta, Lee, In-Kyoung, Yun, Bong-Sik, Matsuzaki, Keiichi, Furukawa, Megumi, Min, Hae-Ki, Bajaj, Jasmohan S., Zhou, Huiping, Hylemon

Journal:

Cell Chemical Biology

Year:

2018

Language:

english

File:

PDF, 3.34 MB

english, 2018

37

The acidic pathway of bile acid synthesis: Not just an alternative pathway

Pandak, William M., Kakiyama, Genta

Journal:

Year:

2019

Language:

english

File:

PDF, 1.48 MB

english, 2019

38

Alterations in Skin Microbiomes of Patients With Cirrhosis

Bajaj, Jasmohan S., Fagan, Andrew, Sikaroodi, Masoumeh, Kakiyama, Genta, Takei, Hajme, Degefu, Yordanos, Pandak, William M., Hylemon, Phillip B., Fuchs, Michael, John, Binu, Heuman, Douglas M., Gavis,

Journal:

Clinical Gastroenterology and Hepatology

Year:

2019

Language:

english

File:

PDF, 4.59 MB

english, 2019

39

243 – Stard5 Plays a Critical Role in the Hepatocyte Er Stress Survival Response

Rodriguez-Agudo, Daniel, Kakiyama, Genta, Zhou, Huiping, Gil, Gregorio, Pandak, William

Journal:

Gastroenterology

Year:

2019

Language:

english

File:

PDF, 694 KB

english, 2019

40

243 – Stard5 Plays a Critical Role in the Hepatocyte Er Stress Survival Response

Rodriguez-Agudo, Daniel, Kakiyama, Genta, Zhou, Huiping, Gil, Gregorio, Pandak, William

Journal:

Gastroenterology

Year:

2019

File:

PDF, 694 KB

2019

41

SAT-012-Alterations in skin microbiota, serum bile acids and autotaxin modulate itching intensity in patients with cirrhosis

Bajaj, Jasmohan S, Fagan, Andrew, Sikaroodi, Masoumeh, Kakiyama, Genta, Pandak, William, Takei, Hajime, Gavis, Edith, Hylemon, Phillip, Heuman, Douglas, Nittono, Hiroshi, Gillevet, Patrick

Journal:

Journal of Hepatology

Year:

2019

Language:

english

File:

PDF, 343 KB

english, 2019

42

Pilot Study of Gut Dysbiosis and Bile Acid Dysmetabolism in Active Ulcerative Colitis

Gaidos, Jill, Kang, Jason D., Kakiyama, Genta, Pandak, William M., Hylemon, Phillip B.

Journal:

American Journal of Gastroenterology

Year:

2019

File:

PDF, 147 KB

2019

43

Progression to Cirrhosis Leads to Improvement in Atherogenic Milieu

Patel, Samarth, Siddiqui, Mohammad B., Chandrakumaran, Anchalia, Rodriguez, Viviana A., Faridnia, Masoud, Hernandez Roman, Jose, Zhang, Emily, Patrone, Michael V., Kakiyama, Genta, Walker, Caroline, S

Journal:

Digestive Diseases and Sciences

Year:

2020

Language:

english

File:

PDF, 910 KB

english, 2020

44

Changes in conjugated urinary bile acids across age groups

Sato, Keiko, Kakiyama, Genta, Suzuki, Mitsuyoshi, Naritaka, Nakayuki, Takei, Hajime, Sato, Hiroaki, Kimura, Akihiko, Murai, Tsuyoshi, Kurosawa, Takao, Pandak, William M., Nittono, Hiroshi, Shimizu, To

Journal:

Year:

2020

File:

PDF, 769 KB

2020

45

Insulin resistance dysregulates CYP7B1 leading to oxysterol accumulation: a pathway for NAFL to NASH transition

Kakiyama, Genta, Marques, Dalila, Martin, Rebecca, Takei, Hajime, Rodriguez-Agudo, Daniel, LaSalle, Sandra A, Hashiguchi, Taishi, Liu, Xiaoying, Green, Richard M., Erickson, Sandra K., Gil, Gregorio,

Journal:

The Journal of Lipid Research

Year:

2020

File:

PDF, 1.35 MB

2020